DNA-associated marks can affect expression without changing DNA sequence.
Key knowledge
Chemical modifications of DNA and associated proteins can affect how cells use genetic information without changing the underlying DNA sequence. Some regulatory states persist through cell division; inheritance across organismal generations is a separate, context-dependent question.
Conditions and scope
Not every mark is causal, persistent or transmitted to offspring.
The NHGRI examples concern human and other mammalian contexts; they do not establish universal transgenerational inheritance of acquired traits.
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References
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Chemical modifications of DNA and associated proteins can affect how cells use genetic information without changing the underlying DNA sequence. Some regulatory states persist through cell division; inheritance across organismal generations is a separate, context-dependent question.
DNA-associated regulatory marks can affect expression without a sequence change.
Eukaryotic nuclear DNA is packaged with histones into nucleosomes and replicated from multiple origins. Linear chromosome ends create an end-replication problem after removal of a terminal RNA primer. Telomerase can extend telomeric DNA using an RNA template; its activity is regulated and varies among cell types.
Chromatin organization can influence accessibility.
Enhancer-bound activators can influence a promoter through protein interactions, including Mediator and chromatin-remodelling or modifying complexes. DNA looping can bring distant regulatory regions into proximity. Promoter context, chromatin and factor combinations determine which genes respond.
For an X-linked locus without a corresponding Y allele in the standard XX/XY model, an XY individual is hemizygous, and reciprocal crosses can yield different genotype distributions. Nuclear sex-linked transmission must be distinguished from organellar inheritance. Mitochondrial and plastid genomes can undergo vegetative segregation as cells divide; parental contributions vary among lineages. Human mitochondrial inheritance is predominantly maternal, while biparental mitochondrial transmission in budding yeast and biparental plastid transmission in some plants illustrate different models.
X inactivation can alter expression while transmission remains chromosome based.