Identifying feedback in signaling networks
This record describes an open question and its evidence. Source review does not resolve the question.
Research context
open question · unresolved · As of 2026-10-10
A delayed response can be explained by feedback, slow transport, state heterogeneity or an unobserved intermediate.
Key knowledge
A delayed response can be explained by feedback, slow transport, state heterogeneity or an unobserved intermediate. Distinguishing these mechanisms requires time-resolved interventions and independently measured states; fitting one feedback diagram is insufficient identification.
Conditions and scope
- Dated open inference problem; model topology, stimulus waveform and observed variables must be specified for a concrete system.
Sources · 2
References
Sources retain their recorded scope. A source link alone does not establish verification of every statement.
- Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihoodAndreas Raue and colleaguesResearch abstract
- Perturb-Seq: dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screensDixit, Parnas and colleaguesResearch paper
Evidence and review
Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood: Original abstract: structural/practical distinction and confidence intervals (indexed author abstract); Perturb-Seq: dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screens: Introduction/results: guide assignment, pooled perturbations and combinatorial effects (indexed primary results/discussion passages)
2026-10-10 · Bounded author source inspection of identifying feedback in signaling networks, including the stated conditions; independent branch review is recorded separately.
Entry details
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- res-bio-feedback-open
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- Postgraduate & research reference