YAP/TAZ mechanical signaling: an intervention study
Research context
study · conditional · As of 2026-10-10
peer reviewed · 2011-06-08
- Study design
- Hydrogels/micropatterns and cytoskeletal or regulator perturbations with localization, transcription and phenotype readouts.
- Reported result
- Supports context-dependent YAP/TAZ mediation of substrate/cell-geometry responses.
- Limitations
- Cultured-cell, material and perturbation contexts bound inference; it is not a complete tissue-growth or mechanochemical constitutive model.
Dupont and colleagues altered substrate rigidity and cell geometry and tested actomyosin/Rho and YAP/TAZ responses in specified cultured mammalian cells.
Key knowledge
Dupont and colleagues altered substrate rigidity and cell geometry and tested actomyosin/Rho and YAP/TAZ responses in specified cultured mammalian cells. Transcriptional, localization and differentiation measurements support mechanical-to-regulatory signaling in those contexts, rather than a universal stiffness-to-fate rule.
Conditions and scope
- Adhesive area, matrix chemistry, stiffness and cell type require controls; localization, target-gene expression and differentiation are different readouts.
Sources · 1
References
Sources retain their recorded scope. A source link alone does not establish verification of every statement.
Evidence and review
Role of YAP/TAZ in mechanotransduction: ECM stiffness/cell shape, actomyosin/Rho perturbation, transcriptional and differentiation readouts (publisher abstract and Hunter/CUNY-hosted original full-text sections)
2026-10-10 · Bounded author source inspection of yap/taz mechanical signaling: an intervention study, including the stated conditions; independent branch review is recorded separately.
Entry details
Permanent link to this entry ↗- Record identity
- res-bio-yap-mechanotransduction
- Revision
- research.1
- Structured reference record
- Postgraduate & research reference