Kinetic isotope effects and mechanism
Research context
research method · established · As of 2026-10-10
Deuterium isotope effects can constrain C–H functionalization pathways, but their interpretation depends on whether rates, competition or product distributions were measured.
Key knowledge
Deuterium isotope effects can constrain C–H functionalization pathways, but their interpretation depends on whether rates, competition or product distributions were measured. A single KIE does not uniquely identify the turnover-limiting elementary step.
Conditions and scope
- Distinguish intermolecular/intramolecular competition from parallel reaction rates; pre-equilibria and commitment factors can alter the observed effect.
Sources · 1
References
Sources retain their recorded scope. A source link alone does not establish verification of every statement.
Evidence and review
On the interpretation of deuterium kinetic isotope effects in C–H bond functionalizations: Author abstract/graphical summary: KIE interpretations depend on experimental design (publisher abstract only)
2026-10-10 · Bounded author source inspection of kinetic isotope effects and mechanism, including the stated conditions; independent branch review is recorded separately.
Entry details
Permanent link to this entry ↗- Record identity
- res-chem-isotope-design
- Revision
- research.1
- Structured reference record
- Postgraduate & research reference