Base excision versus nucleotide excision repair
Base-excision repair begins when a glycosylase removes a recognized damaged base, leaving a site that is processed and restored by DNA synthesis and ligation.
Key knowledge
Base-excision repair begins when a glycosylase removes a recognized damaged base, leaving a site that is processed and restored by DNA synthesis and ligation. Nucleotide-excision repair instead removes a DNA segment containing a recognized lesion. Both use the complementary strand as an informational template when that template remains available.
Conditions and scope
- Substrate recognition, processing enzymes and patch size depend on pathway and organism.
- This contrast does not imply that all DNA lesions are repaired by either one route or without errors.
Sources · 1
References
Sources retain their recorded scope. A source link alone does not establish verification of every statement.
Evidence and review
Read indexed glycosylase/abasic-site and segment-excision repair paragraphs; the check covers these paragraphs, not the complete book or enzyme census.
2026-10-10 · Independent AI editorial review: All 115 actual compact claims, hypotheses, equation/variable/unit tables and 251 origin semantic links independently read. All exact author source-binding rows and disclosed extents assessed; targeted original bodies or specifically identified indexed primary passages rechecked below. All retained biology compact records read for combined breadth. Independent AI editorial content and practical common-core inventory review; no human specialist, degree/laboratory proficiency, whole-textbook certification or experimental replication. Receipt: biology-independent-content-inventory-review.1.
Entry details
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- uni-bio-base-excision
- Revision
- core.1
- Structured reference record
- University core expansion