Cyclins, CDKs and cell-cycle checkpoints
Cyclin abundance and cyclin-dependent kinase regulation help order cell-cycle transitions.
Key knowledge
Cyclin abundance and cyclin-dependent kinase regulation help order cell-cycle transitions. Checkpoints can delay progression when DNA is damaged, replication is incomplete or chromosomes are improperly attached to the spindle. The G1, G2/M and spindle checkpoints assess different constraints.
Conditions and scope
- Checkpoint components and responses vary among organisms and cells.
- Passing a checkpoint reduces a particular error risk; it does not prove a cell is free from every defect.
Sources · 1
References
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Evidence and review
Read checkpoint conditions and cyclin/CDK regulators.
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Entry details
Permanent link to this entry ↗- Record identity
- uni-bio-cell-cycle-checkpoints
- Revision
- core.1
- Structured reference record
- University core expansion