Endocrine axes and negative feedback
In the vertebrate thyroid-axis example, hypothalamic signals stimulate pituitary hormone release, which stimulates the thyroid.
Key knowledge
In the vertebrate thyroid-axis example, hypothalamic signals stimulate pituitary hormone release, which stimulates the thyroid. Rising thyroid-hormone concentrations inhibit upstream stimulation. Neural and blood-chemical signals can also trigger endocrine secretion, so endocrine control is a connected feedback system rather than a hormone acting in isolation.
Conditions and scope
- The thyroid example is one regulatory axis, not every endocrine pathway.
- Feedback targets and timescales differ; positive feedback also occurs in particular contexts.
Sources · 1
References
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Evidence and review
Read hypothalamus/pituitary/thyroid negative-feedback sequence and humoral/neural control distinction; excluded disease/treatment claims.
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Entry details
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- uni-bio-endocrine-feedback
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- core.1
- Structured reference record
- University core expansion