Secretory and endomembrane trafficking
In the eukaryotic secretory pathway, many membrane and exported proteins enter the rough endoplasmic reticulum, undergo processing and move in vesicles through the Golgi toward selected destinations.
Key knowledge
In the eukaryotic secretory pathway, many membrane and exported proteins enter the rough endoplasmic reticulum, undergo processing and move in vesicles through the Golgi toward selected destinations. Endomembrane compartments coordinate synthesis, modification, sorting and degradation. Mitochondria and chloroplasts are not simply downstream secretory vesicles.
Conditions and scope
- Protein targeting depends on molecular signals and trafficking machinery; the pathway does not apply to every protein.
- Compartment lumen and cytosolic faces preserve distinct topologies during vesicle traffic.
Sources · 1
References
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Evidence and review
Read ER/Golgi/vesicle secretory route and exclusion of mitochondrial/chloroplast membranes.
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Entry details
Permanent link to this entry ↗- Record identity
- uni-bio-endomembrane-trafficking
- Revision
- core.1
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- University core expansion