Signal recognition and ER translocation
In the canonical secretory route, SRP recognizes an emerging signal sequence and targets the ribosome–nascent-chain complex to the ER receptor and Sec61 channel.
Key knowledge
In the canonical secretory route, SRP recognizes an emerging signal sequence and targets the ribosome–nascent-chain complex to the ER receptor and Sec61 channel. Continued synthesis and translocation deliver a soluble secretory protein into the lumen. Other ER targeting routes can act after translation.
Conditions and scope
- Not every signal is cleaved and membrane proteins require topology-specific insertion.
- This canonical model does not exhaust SRP-independent routes.
Sources · 1
References
Sources retain their recorded scope. A source link alone does not establish verification of every statement.
Evidence and review
Read indexed SRP/receptor/Sec61 and posttranslational/BiP paragraphs; full retrieval blocked. Excludes universal cotranslational targeting.
2026-10-10 · Independent AI editorial review: All 115 actual compact claims, hypotheses, equation/variable/unit tables and 251 origin semantic links independently read. All exact author source-binding rows and disclosed extents assessed; targeted original bodies or specifically identified indexed primary passages rechecked below. All retained biology compact records read for combined breadth. Independent AI editorial content and practical common-core inventory review; no human specialist, degree/laboratory proficiency, whole-textbook certification or experimental replication. Receipt: biology-independent-content-inventory-review.1.
Entry details
Permanent link to this entry ↗- Record identity
- uni-bio-er-translocation
- Revision
- core.1
- Structured reference record
- University core expansion