Canonical fatty acid β-oxidation
For a typical saturated even-chain fatty acyl-CoA, β-oxidation repeats oxidation, hydration, oxidation and thiolytic cleavage.
Key knowledge
For a typical saturated even-chain fatty acyl-CoA, β-oxidation repeats oxidation, hydration, oxidation and thiolytic cleavage. Each nonterminal turn yields an acetyl-CoA, NADH and reduced flavin equivalent while shortening the acyl chain by two carbons. The terminal four-carbon cleavage yields two acetyl-CoA.
Conditions and scope
- Activation and transport consume resources; long-chain mitochondrial entry can require a carnitine shuttle.
- Odd-chain, unsaturated and peroxisomal pathways require additional or different accounting.
Sources · 1
References
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Evidence and review
Read acyl-CoA/carnitine import and four-step repeating oxidation/thiolysis description; bounded even-chain mitochondrial model.
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Entry details
Permanent link to this entry ↗- Record identity
- uni-bio-fatty-acid-oxidation
- Revision
- core.1
- Structured reference record
- University core expansion