Gluconeogenesis and irreversible-step bypasses
Gluconeogenesis makes glucose from suitable noncarbohydrate precursors.
Key knowledge
Gluconeogenesis makes glucose from suitable noncarbohydrate precursors. It shares reversible steps with glycolysis but uses distinct bypasses for the strongly driven glycolytic steps, including pyruvate carboxylase/PEP carboxykinase, fructose-bisphosphatase and glucose-6-phosphatase in the described mammalian pathway. Net synthesis consumes energy.
Conditions and scope
- Precursor contributions and compartments depend on species and tissue.
- In mammals, acetyl-CoA from ordinary even-chain fatty acids cannot provide net glucose through the canonical TCA/gluconeogenic route.
Sources · 1
References
Sources retain their recorded scope. A source link alone does not establish verification of every statement.
Evidence and review
Read pathway overview and named bypass enzymes; source's PEP-CK label corrected to phosphoenolpyruvate carboxykinase; no fixed blood concentration claims used.
2026-10-10 · Independent AI editorial review: All 115 actual compact claims, hypotheses, equation/variable/unit tables and 251 origin semantic links independently read. All exact author source-binding rows and disclosed extents assessed; targeted original bodies or specifically identified indexed primary passages rechecked below. All retained biology compact records read for combined breadth. Independent AI editorial content and practical common-core inventory review; no human specialist, degree/laboratory proficiency, whole-textbook certification or experimental replication. Receipt: biology-independent-content-inventory-review.1.
Entry details
Permanent link to this entry ↗- Record identity
- uni-bio-gluconeogenesis
- Revision
- core.1
- Structured reference record
- University core expansion