Heterotrimeric G-protein receptor cycle
An activated GPCR promotes GDP release and GTP binding on a heterotrimeric G protein's α subunit.
Key knowledge
An activated GPCR promotes GDP release and GTP binding on a heterotrimeric G protein's α subunit. Activated α and βγ can regulate effectors such as enzymes or ion channels. GTP hydrolysis helps terminate α signalling and reset the cycle.
Conditions and scope
- Receptor, G-protein class and cellular effectors determine the response; not every pathway raises cyclic AMP.
Sources · 1
References
Sources retain their recorded scope. A source link alone does not establish verification of every statement.
Evidence and review
Read indexed nucleotide-exchange, α/βγ effector and hydrolysis text; excludes obligatory complete subunit separation in all settings.
2026-10-10 · Independent AI editorial review: All 115 actual compact claims, hypotheses, equation/variable/unit tables and 251 origin semantic links independently read. All exact author source-binding rows and disclosed extents assessed; targeted original bodies or specifically identified indexed primary passages rechecked below. All retained biology compact records read for combined breadth. Independent AI editorial content and practical common-core inventory review; no human specialist, degree/laboratory proficiency, whole-textbook certification or experimental replication. Receipt: biology-independent-content-inventory-review.1.
Entry details
Permanent link to this entry ↗- Record identity
- uni-bio-heterotrimeric-gprotein
- Revision
- core.1
- Structured reference record
- University core expansion