Linkage and recombination mapping
Linked loci share a chromosome; meiotic recombination can separate their alleles.
Key knowledge
Linked loci share a chromosome; meiotic recombination can separate their alleles. Recombinant offspring fractions estimate linkage distances for sufficiently close loci. In the standard Mendelian linkage model, the expected recombinant fraction is at most one half; a finite scored offspring sample can exceed that value through sampling fluctuation or distorted class recovery. Multiple crossovers can hide events, so this fraction is not a linear measure of large physical distances.
Conditions and scope
- Specify the cross, informative genotypes and scoring assumptions; the standard expected-fraction bound assumes ordinary chromatid participation and no segregation or viability distortion.
- One percent recombination defines one map unit in the short-distance convention; mapping functions and physical base-pair distances are distinct.
Sources · 1
References
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Evidence and review
Reread linkage/mapping and theoretical 50-percent maximum passage. Distinguished the standard model expectation from finite sampled offspring counts and class distortion; the sampling distinction follows from treating the scored fraction as an estimator, not a probability constrained in every realized sample.
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Entry details
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- uni-bio-linkage-mapping
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- core.1
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- University core expansion