Mitochondrial protein targeting and import
Many nuclear-encoded mitochondrial matrix proteins carry targeting sequences recognized by TOM and transferred through the TIM23 pathway.
Key knowledge
Many nuclear-encoded mitochondrial matrix proteins carry targeting sequences recognized by TOM and transferred through the TIM23 pathway. Chaperones maintain import competence; inner-membrane potential and ATP-dependent chaperone action support import. Carrier and membrane proteins use distinct sorting routes.
Conditions and scope
- The matrix-presequence model is not all mitochondrial protein import.
- Posttranslational import is common but not universal; targeting signals can differ.
Sources · 1
References
Sources retain their recorded scope. A source link alone does not establish verification of every statement.
Evidence and review
Read indexed presequence, TOM/TIM23, chaperone and potential/ATP paragraphs; full retrieval blocked. Excludes universal all-TOM/posttranslational-only wording.
2026-10-10 · Independent AI editorial review: All 115 actual compact claims, hypotheses, equation/variable/unit tables and 251 origin semantic links independently read. All exact author source-binding rows and disclosed extents assessed; targeted original bodies or specifically identified indexed primary passages rechecked below. All retained biology compact records read for combined breadth. Independent AI editorial content and practical common-core inventory review; no human specialist, degree/laboratory proficiency, whole-textbook certification or experimental replication. Receipt: biology-independent-content-inventory-review.1.
Entry details
Permanent link to this entry ↗- Record identity
- uni-bio-mitochondrial-import
- Revision
- core.1
- Structured reference record
- University core expansion