Receptor tyrosine kinase and Ras signalling
Activation of a receptor tyrosine kinase can create phosphotyrosine docking sites for adaptors and enzymes.
Key knowledge
Activation of a receptor tyrosine kinase can create phosphotyrosine docking sites for adaptors and enzymes. In a representative pathway, Grb2/Sos recruitment promotes GDP-to-GTP exchange on Ras, which activates a kinase cascade including MAP kinases. GAP-enhanced GTP hydrolysis helps turn Ras off.
Conditions and scope
- Receptor and tissue context can use other branches; Ras and heterotrimeric G proteins are distinct.
- No universal proliferation response or clinical mutation frequency is asserted.
Sources · 1
References
Sources retain their recorded scope. A source link alone does not establish verification of every statement.
Evidence and review
Read indexed SH2 docking, Grb2/Sos and Ras-switch paragraphs; omitted dated tumour frequency and permanent-lock language.
2026-10-10 · Independent AI editorial review: All 115 actual compact claims, hypotheses, equation/variable/unit tables and 251 origin semantic links independently read. All exact author source-binding rows and disclosed extents assessed; targeted original bodies or specifically identified indexed primary passages rechecked below. All retained biology compact records read for combined breadth. Independent AI editorial content and practical common-core inventory review; no human specialist, degree/laboratory proficiency, whole-textbook certification or experimental replication. Receipt: biology-independent-content-inventory-review.1.
Entry details
Permanent link to this entry ↗- Record identity
- uni-bio-receptor-kinase-ras
- Revision
- core.1
- Structured reference record
- University core expansion