Base-editing chemistry and repair context
Research context
research method · established · As of 2026-10-10
Cytidine base editors couple a deaminase with DNA-targeting Cas9 machinery; UGI and nicking modifications bias processing toward desired substitutions.
Key knowledge
Cytidine base editors couple a deaminase with DNA-targeting Cas9 machinery; UGI and nicking modifications bias processing toward desired substitutions. Editing windows, sequence context and cellular repair shape products, including bystander changes and unwanted outcomes.
Conditions and scope
- The 2016 experiments tested specified cell lines and constructs; avoid extrapolating their efficiency or product purity to every tissue.
Sources · 1
References
Sources retain their recorded scope. A source link alone does not establish verification of every statement.
Evidence and review
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage: Deaminase/Cas9 fusion, UGI/nickase modification and cell-line testing (indexed original results passages)
2026-10-10 · Bounded author source inspection of base-editing chemistry and repair context, including the stated conditions; independent branch review is recorded separately.
Entry details
Permanent link to this entry ↗- Record identity
- res-bio-base-editing
- Revision
- research.1
- Structured reference record
- Postgraduate & research reference