Phasing and independent structural checks
Research context
research method · established · As of 2026-10-10
Phase probabilities and map weighting affect reconstructed density, and model-derived phases can bias the apparent support for that same model.
Key knowledge
Phase probabilities and map weighting affect reconstructed density, and model-derived phases can bias the apparent support for that same model. Examine experimental phase information, uncertainty and independent validation rather than reading every map peak as an established atom.
Conditions and scope
- Noise, resolution and phase uncertainty limit interpretation; compare alternative occupancy/conformation models where the data cannot distinguish them.
Sources · 1
References
Sources retain their recorded scope. A source link alone does not establish verification of every statement.
Evidence and review
Experimental phasing: best practice and pitfalls: Section 4: probabilistic phases, Fourier maps and model bias (relevant original article sections)
2026-10-10 · Bounded author source inspection of phasing and independent structural checks, including the stated conditions; independent branch review is recorded separately.
Entry details
Permanent link to this entry ↗- Record identity
- res-chem-phasing-bias
- Revision
- research.1
- Structured reference record
- Postgraduate & research reference