Suzuki transmetalation as a conditional pathway comparison
Research context
study · conditional · As of 2026-10-10
peer reviewed · 2011-01-31
- Study design
- Stoichiometric intermediate characterization, populations and relative transmetalation-rate comparisons.
- Reported result
- Supports a conditional hydroxo-palladium/boronic-acid route in weak-base aqueous conditions.
- Limitations
- Scope excludes generalizing to all ligands, strong bases, anhydrous or biphasic systems.
Carrow and Hartwig compared isolated palladium hydroxo/halide and boronic-acid/boronate species and their rates.
Key knowledge
Carrow and Hartwig compared isolated palladium hydroxo/halide and boronic-acid/boronate species and their rates. Their weak-base aqueous-mixture evidence favors a hydroxo-palladium/boronic-acid route under those conditions, rather than proving one transmetalation pathway for all Suzuki reactions.
Conditions and scope
- Different bases, water activity, ligands, phase transfer and concentrations can change species and pathways; no universal resting-state assignment is made.
Sources · 1
References
Sources retain their recorded scope. A source link alone does not establish verification of every statement.
Evidence and review
Distinguishing between pathways for transmetalation in Suzuki–Miyaura reactions: Isolated intermediates and relative rates; conclusion restricted to weak-base aqueous mixtures (original paper abstract and extracted author text via indexed PDF)
2026-10-10 · Bounded author source inspection of suzuki transmetalation as a conditional pathway comparison, including the stated conditions; independent branch review is recorded separately.
Entry details
Permanent link to this entry ↗- Record identity
- res-chem-suzuki-pathways
- Revision
- research.1
- Structured reference record
- Postgraduate & research reference