Nonhomologous DNA end joining
End joining can restore continuity of a double-strand-broken DNA molecule without using a long homologous donor template.
Key knowledge
End joining can restore continuity of a double-strand-broken DNA molecule without using a long homologous donor template. Processing and ligation can preserve or change sequence at the junction. This differs from homology-directed repair, whose strand invasion uses another DNA molecule as a template.
Conditions and scope
- End chemistry, processing and pathway choice affect junction fidelity.
- No claim that every end-joining event loses bases or that a noncoding junction is biologically harmless.
Sources · 1
References
Sources retain their recorded scope. A source link alone does not establish verification of every statement.
Evidence and review
Read indexed juxtaposition/ligation and homologous-versus-nonhomologous contrast; excluded dated organismal prevalence and assertion that coding fraction makes errors acceptable.
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Entry details
Permanent link to this entry ↗- Record identity
- uni-bio-end-joining
- Revision
- core.1
- Structured reference record
- University core expansion