Receptors, second messengers and signal transduction
A receptor can convert ligand binding into an intracellular response through protein conformational changes, phosphorylation cascades or second messengers such as cyclic AMP and calcium.
Key knowledge
A receptor can convert ligand binding into an intracellular response through protein conformational changes, phosphorylation cascades or second messengers such as cyclic AMP and calcium. Amplification and feedback shape the response. Different receptors and cell states can produce different outcomes from the same extracellular signal.
Conditions and scope
- Kinases add phosphate groups while phosphatases remove them; phosphorylation can activate or inhibit a particular target.
- Some signals act through intracellular receptors rather than plasma-membrane receptors.
Sources · 2
References
Sources retain their recorded scope. A source link alone does not establish verification of every statement.
Mary Ann Clark, Matthew Douglas and Jung Choi — OpenStax, Rice University2 sources
Evidence and review
Read kinase/phosphatase and second-messenger propagation and cell-dependent response; avoided membrane-receptor universalization.
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Entry details
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- uni-bio-signal-transduction
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- core.1
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- University core expansion