Translation initiation and start-site selection
Canonical eukaryotic initiation recruits a small ribosomal complex near the capped mRNA end and scans for a start codon in a suitable context.
Key knowledge
Canonical eukaryotic initiation recruits a small ribosomal complex near the capped mRNA end and scans for a start codon in a suitable context. Bacterial ribosome-binding interactions can position an internal start site. Initiator tRNA establishes the reading frame before elongation.
Conditions and scope
- Leaky scanning and alternative initiation occur; neither first-AUG recognition nor Shine–Dalgarno use is universal.
Sources · 1
References
Sources retain their recorded scope. A source link alone does not establish verification of every statement.
Evidence and review
Inspected indexed scanning, context and bacterial binding paragraphs; full retrieval blocked. Excludes source caption's transcription/translation typo.
2026-10-10 · Independent AI editorial review: All 115 actual compact claims, hypotheses, equation/variable/unit tables and 251 origin semantic links independently read. All exact author source-binding rows and disclosed extents assessed; targeted original bodies or specifically identified indexed primary passages rechecked below. All retained biology compact records read for combined breadth. Independent AI editorial content and practical common-core inventory review; no human specialist, degree/laboratory proficiency, whole-textbook certification or experimental replication. Receipt: biology-independent-content-inventory-review.1.
Entry details
Permanent link to this entry ↗- Record identity
- uni-bio-translation-initiation
- Revision
- core.1
- Structured reference record
- University core expansion