Carbonyl reduction by hydride transfer
Hydride-transfer reduction of an aldehyde or ketone forms an alkoxide that can be protonated to an alcohol.
Key knowledge
Hydride-transfer reduction of an aldehyde or ketone forms an alkoxide that can be protonated to an alcohol. Aldehydes give primary alcohols and ketones secondary alcohols in this reference transformation. Reducing-agent chemistry controls which carbonyl classes react.
Conditions and scope
- A hydride-donor model does not imply free hydride in the medium.
- Functional-group selectivity, stereochemistry and competing reactions require the specified reagent and substrate; no preparation protocol is supplied.
Sources · 1
References
Sources retain their recorded scope. A source link alone does not establish verification of every statement.
Evidence and review
Read hydride-donor/alkoxide/protonation mechanism; excluded universal reagent equivalence and synthetic yields.
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Entry details
Permanent link to this entry ↗- Record identity
- uni-chem-carbonyl-hydride-reduction
- Revision
- core.1
- Structured reference record
- University core expansion