Stepwise E1 and E1cB elimination
E1 elimination proceeds through ionization followed by loss of a proton from a carbocation intermediate.
Key knowledge
E1 elimination proceeds through ionization followed by loss of a proton from a carbocation intermediate. E1cB proceeds through a conjugate-base intermediate before leaving-group loss. The charge and order of steps differ, so substrate acidity, intermediate stabilization and leaving-group properties affect which description is appropriate.
Conditions and scope
- A single rate-limiting step and irreversible sequence are models that need kinetic evidence.
- E1 can compete with SN1; E1cB rate control is not universally proton removal.
Sources · 1
References
Sources retain their recorded scope. A source link alone does not establish verification of every statement.
Evidence and review
Inspected intermediate charge, step order and substitution competition; avoid universalizing the source's illustrative E1cB rate-limiting step.
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Entry details
Permanent link to this entry ↗- Record identity
- uni-chem-e1-e1cb
- Revision
- core.1
- Structured reference record
- University core expansion